Nick's feeling distressed from the sodium methoxide turning into sodium hydoxide, which converted the hydroxylamine group back into an acid. But that's alright. He's not been having a nice time lately, especially since he broke up with Gillian. But his reason for happiness hasn't been easy, and people breathe down hard on him, and he's feeling really disarrayed.

Nick's only happy when you guys are there, coz you guys make me smile.

I'll give you a chance, I agree with them that I've been really hard on you. But you don't give crap either. I want you to work really hard, or don't blame me for treating you the way I have always done.